| Description | JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors. |
| Target activity | Y2 receptor (human):8.07(pIC50), Y2 receptor (rat):8.22(pIC50) |
| Synonyms | JNJ 31020028 |
| molecular weight | 565.68 |
| Molecular formula | C34H36FN5O2 |
| CAS | 1094873-14-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.5 mg/mL (9.72 mM) |
| References | 1. Shoblock JR, et al. Psychopharmacology (Berl). 2010 Feb;208(2):265-77. |