| Description | GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). |
| Target activity | PI3Kγ:10.2 nM(Ki), PI3Kα:0.2 nM(Ki), PI3Kβ:26.6 nM(Ki), PI3Kδ:4 nM(Ki) |
| Synonyms | GDC 0326, GDC0326 |
| molecular weight | 382.42 |
| Molecular formula | C19H22N6O3 |
| CAS | 1282514-88-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 69 mg/mL (180.5 mM) H2O: Insoluble |
| References | 1. Heffron TP., et al. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). J Med Chem. 2016 Feb 11;59(3):985-1002. |