| Description | FV-100 (Valnivudine HCl) is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.FV-100 is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo. |
| In vitro | FV-100 (1 h) 在HeLa细胞中产生不同的分布。[1] |
| In vivo | FV-100（50-500 mg/kg；口服）在大鼠中不会引起与生物学相关的呼吸变化或显著的神经药理学效应。[2] |
| Synonyms | Valnivudine HCl |
| molecular weight | 534.04 |
| Molecular formula | C27H36ClN3O6 |
| CAS | 956483-03-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Migliore M, et, al. FV-100: the most potent and selective anti-varicella zoster virus agent reported to date. Antivir Chem Chemother. 2010 ; 20(3):107-115. 2. Pentikis HS, et, al. Pharmacokinetics and safety of FV-100, a novel oral anti-herpes zoster nucleoside analogue, administered in single and multiple doses to healthy young adult and elderly adult volunteers. Antimicrob Agents Chemother. 2011 ; 55(6):2847-2854. |