| Description | Fumonisin B1 (Fumonisin-B1) is a mycotoxin produced by Fusarium oxysporum that is widely present in crops, contaminating them and posing a significant food safety hazard.Fumonisin B1 is structurally a sphingosine and sphingomyelin analog, and inhibits the biosynthesis of complex sphingolipids through the inhibition of ceramidic synthases. |
| In vitro | 0.1 μmol/L Fumonisin B1 处理后 P21 的 mRNA 表达显著增加，10.0和100.0 μmol/L Fumonisin B1 处理后 P21 的 mRNA 表达显著降低[1]。 |
| Synonyms | Fumonisin-B1 |
| molecular weight | 721.83 |
| Molecular formula | C34H59NO15 |
| CAS | 116355-83-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 16 mg/mL (22.17 mM), Sonication is recommended. Methanol: 5 mg/mL (6.93 mM), Sonication is recommended. |
| References | 1. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. 2. Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34. 3. Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6. |