| Description | PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM). |
| In vivo | PF-06424439在大鼠体内通过静脉给药后表现出中等的清除率，并且中等的稳态分布体积（Vdss）导致半衰期短[1]。 |
| Target activity | DGAT-2:14 nM |
| molecular weight | 439.94 |
| Molecular formula | C22H26ClN7O |
| CAS | 1469284-78-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Futatsugi K, et al. Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). J Med Chem. 2015 Sep 24;58(18):7173-85. 2. Pabst B, et al. Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Biochemistry. 2018 Dec 26;57(51):6997-7010. |