| Description | FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM). |
| In vitro | 在斑马鱼胚胎中,FLI-06（50uM）可使内源性的Notch信号被抑制. |
| In vivo | 在肾上皮细胞系293细胞中,稳定转染突变型的APP可产生大量的淀粉样沉淀。FLI-06可使APP的成熟模式改变,从而终止APPs的释放。在过表达Notch绿色荧光蛋白的Hela细胞中,FLI-06抑制Notch的转运和进程。FLI-06可破坏高尔基复合体,在内质网从管状转换到片状形态的过程中,使内质网转运前总蛋白的分泌受到抑制。 |
| Target activity | Notch:2.3 μM(EC50) |
| Synonyms | FLI 06 |
| molecular weight | 438.52 |
| Molecular formula | C25H30N2O5 |
| CAS | 313967-18-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 8.8 mg/mL (20 mM) DMSO: 60 mg/mL (136.82 mM) |
| References | 1. Krämer A, et al. Nat Chem Biol. 2013, 9(11), 731-738. |