| Description | Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia. |
| Synonyms | CGP 63446, ACEA1021, ACEA 1021, ACEA-1021, CGP-63446 |
| molecular weight | 276.03 |
| Molecular formula | C8H3Cl2N3O4 |
| CAS | 153504-81-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (199.25 mM) |
| References | 1. Qiu W, Wei R, Zhang C, Zhang C, Leng W, Wang W. A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades. J Cell Physiol. 2010 Jun;223(3):819-26. doi: 10.1002/jcp.22118. PubMed PMID: 20333677. 2. Cai SX. Glycine/NMDA receptor antagonists as potential CNS therapeutic agents: ACEA-1021 and related compounds. Curr Top Med Chem. 2006;6(7):651-62. PubMed PMID: 16719807. 3. Petty MA, Weintraub PM, Maynard KI. ACEA 1021: flip or flop? CNS Drug Rev. 2004 Winter;10(4):337-48. Review. PubMed PMID: 15592582. 4. Wiley JL, Balster RL. Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats. Life Sci. 2004 May 28;75(2):141-51. PubMed PMID: 15120567. |