| Description | Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS). Estrone O-sulfamate is a placental microsomal inhibitor (P.M.) with IC50 values of 18 nM. Estrone O-sulfamate showed inhibitory effects on STS in MCF-7 cells with IC50 values of 0.83 nM. Estrone O-sulfamate can be used to study cancer. |
| In vitro | 在胎盘微粒体(P.M.)制备物和MCF-7细胞中，Estrone O-sulfamate（Estrone 3-O-sulfamate）对STS显示出抑制作用，其IC50值分别为18 nM和0.83 nM[1]。 |
| Target activity | STS (MCF-7 cells):0.83 nM, STS (P.M.):18 nM |
| Synonyms | Estrone 3-O-sulfamate |
| molecular weight | 349.44 |
| Molecular formula | C18H23NO4S |
| CAS | 148672-09-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (157.39 mM) |
| References | 1. L W Lawrence Woo, et al. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorg Med Chem. 2012 Apr 15;20(8):2506-19. |