| Description | Edecesertib (GS 5718) is a selective and orally effective inhibitor of interleukin-1 receptor-associated kinase-4 (IRAK-4) with anti-inflammatory activity for the study of rheumatoid arthritis. |
| Synonyms | GS5718, GS-5718, GS 5718 |
| molecular weight | 435.45 |
| Molecular formula | C22H22FN7O2 |
| CAS | 2408839-73-4 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (183.72 mM), Sonication is recommended. |
| References | 1. Roedder S, et al. Phase 1 Study Results of GS-5718, an Oral IRAK4-Inhibitor: Pharmacodynamics of Single and Multiple Doses of GS-5718 in Healthy Subjects. 2021 Nov 6. 2. Stephen Ammann,et al.PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES:US20210214363A1. |