| Description | DHPG ((RS)-3,5-DHPG) ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. It is an amino acid that can be used as a selective and potent agonist for Group I mGluR (mGluR 1 and mGluR 5) and has no effect on Group II or Group III mGluRs . |
| Synonyms | (RS)-3,5-DHPG, DL-Α-(3,5-二羟基苯基)甘氨酸 |
| molecular weight | 183.16 |
| Molecular formula | C8H9NO4 |
| CAS | 146255-66-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL (5.46 mM), Sonication is recommended. H2O: 1 mg/mL (5.46 mM), Sonication is recommended. |
| References | 1. Winder DG, et al. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9. 2. Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43. |