| Description | GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. |
| In vitro | GET73（1 μM, 10 μM；1小时）在慢性乙醇暴露前1小时及期间使用，可以防止乙醇导致的细胞活性下降、细胞骨架结构改变、活性氧物质产生增加和胞外谷氨酸水平降低。 |
| In vivo | GET73在暴露于高架十字迷宫(EPM)测试的斯普莱格-道利(Sprague-Dawley)大鼠中表现出抗焦虑作用。 |
| Synonyms | Gamma hydroxybutyric acid analogue, GET 73 |
| molecular weight | 275.27 |
| Molecular formula | C13H16F3NO2 |
| CAS | 202402-01-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 97 mg/mL (352.38 mM), Sonication is recommended. |
| References | 1. Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35. 2. Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71. 3. Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8. |