| Description | Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses. |
| In vitro | Dehydroepiandrosterone sulfate 在直接作用于分隔前视区神经元时，选择性地增加含有树突标记MAP-2的神经突长度，并增加神经元的兴奋性[1]。 |
| In vivo | 长期给予Dehydroepiandrosterone sulfate对性能产生剂量依赖性效果。在雄性Sprague-Dawley大鼠中，Dehydroepiandrosterone sulfate（5-20 mg/kg；s.c.）显著有效地改善到达平台的潜伏时间[3]。 |
| Synonyms | PB 005, PB005, Prasterone sulfate, DHEA sulfate, DHEAS, PB-005 |
| molecular weight | 368.49 |
| Molecular formula | C19H28O5S |
| CAS | 651-48-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 91.8 mg/mL (249.1 mM), Sonication is recommended. |
| References | 1. do Vale S, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach. Horm Behav. 2015 Jul;73:94-103. 2. E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. 3. C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. 4. Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. |