| Description | Uk-390957 is a sulfonamide compound with a high BPR due to binding to carbonic anhydrase. |
| Target activity | SERT:0.004 µM, SERT:<= 0.1 µM |
| Synonyms | Uk390957, Uk 390957 |
| molecular weight | 352.47 |
| Molecular formula | C16H20N2O3S2 |
| CAS | 364321-71-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (156.04 mM) |
| References | 1. Small H, et al. Measurement of binding of basic drugs to acidic phospholipids using surface plasmon resonance and incorporation of the data into mechanistic tissue composition equations to predict steady-state volume of distribution. Drug Metab Dispos. 2011;39(10):1789-1793. 2. Middleton DS, et al. Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines. Bioorg Med Chem Lett. 2008;18(19):5303-5306. 3. Andrews, et al. Preparation of diphenyl ether compounds as serotonin re-uptake inhibitors. WO2001072687 A1. |