| Description | CTP Synthetase-IN-1 Ammonium salt is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antimicrobial, anti-inflammatory and antitumor activity for the study of SARS-CoV-2 viral infections. |
| In vivo | 在小鼠胶原诱导性关节炎（CIA）模型中，CTP Synthetase-IN-1 Ammonium salt（10 mg/kg 和 50 mg/kg；口服，每日两次，持续 18 天）能够改善特定疾病严重程度的指标[1]。 |
| Target activity | CTPS2 (human):18 nM, CTPS1 (human):32 nM |
| Synonyms | CTPS-IN-1 Ammonium salt, CTP Synthetase-IN-1 Ammonium salt（2338811-71-3 Free base) |
| molecular weight | 529.56 |
| Molecular formula | C20H22F3N7O3S2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (156.09 mM), Sonication is recommended. |
| References | 1. Andrew Novak, et al. Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem. 2022 Dec 22;65(24):16640-16650. |