| Description | Dropropizine (UCB-1967), a racemic non-opiate antitussive agent, is served as a cough suppressant. |
| In vitro | Dropropizine（100 mg/kg）的止咳效果与S. althaeae粘液类似,对机械刺激引发咳嗽的效果低于E. officinalis. 按体重口服 EEPF（200 mg/kg）与按体重腹腔注射Dropropizine（100 mg/kg）具有相似的止咳活性.在处理猫上,Dropropizine 的止咳活性显著低于吡那地尔和可待因.在治疗未麻醉猫机械刺激引发的咳嗽时, Dropropizine产生28.3%止咳活性,Prenoxdiazine则为24.7%. |
| In vivo | Dropropizine对中国仓鼠V79和人类EUE细胞没有致突变和畸变作用, 碳酸锂表现出弱的、马吲哚表现出中等的遗传毒性反应,在微粒体部分S9存在下两种情况下均降低。 |
| Synonyms | (±)-Dropropizine, UCB-196, 羟丙哌嗪, UCB-1967 |
| molecular weight | 236.31 |
| Molecular formula | C13H20N2O2 |
| CAS | 17692-31-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 9 mg/mL (38.1 mM) DMSO: 55 mg/mL (232.75 mM) Ethanol: 44 mg/mL (186.2 mM) |
| References | 1. Nosalova G, et al. Acta Vet. Brno, 2007, 76, 27-33. 2. Slamenová D, et al. Mutat Res, 1986, 169(3), 171-177 3. Sutovska M, et al. Bratisl Lek Listy, 2009, 110(5), 269-275. |