| Description | SPOP-IN-6b is an effective inhibitor of speckle-type POZ protein (SPOP) with an IC50 of 3.58 μM and can be used in stuides about the treatment of renal cancer. |
| In vitro | SPOP-IN-6b（0.1-3.0 μM）通过抑制SPOP活性进而增加肿瘤抑制底物蛋白PTEN和DUSP7的含量。其对A498、Caki-2、Ketr-3、769-P、0S-RC-2以及786-0细胞的IC50值介于2-10.2 μM之间[1]。 |
| In vivo | 在裸鼠体内，SPOP-IN-6b（40-80 mg/kg；i.p.）能够减缓肿瘤生长[1]。 |
| Synonyms | 2-Imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide |
| molecular weight | 500.59 |
| Molecular formula | C28H32N6O3 |
| CAS | 2136270-20-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
| References | 1. Guangcai Y, et al. The pyrido-pyrimidines of 2- imines -5- ketone group -2,5- dihydros -1-H- two. CN107141287A. |