| Description | CP-544439 is an orally active and potent MMP-13 inhibitor that prevents diet-induced obesity and inhibits adipogenesis in 3T3-L1 preadipocytes in mice, and can be used for the study of obesity. |
| In vivo | CP-544439 在大鼠体内分布在除中枢神经系统以外的所有组织中。除牙周韧带外，放射性标记从大多数组织中迅速消除[1]。 |
| Target activity | MMP12:0.24 nM, MMP14:7.4 nM, MMP13:0.75 nM, MMP2:1.6 nM, MMP9:12 nM, MMP8:1.4 nM, MMP3:16 nM, MMP1:420 nM |
| Synonyms | CP 544439, CP544439, UNII-516DO4KL5R |
| molecular weight | 410.42 |
| Molecular formula | C18H19FN2O6S |
| CAS | 230954-09-3 |
| Storage | keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544439 in plasma and urine of humans. Drug Metab Dispos. 2008 Sep;36(9):1869-83. 2. Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395. |