| Description | PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM. |
| In vitro | PF-00356231 hydrochloride 对 MMP-13、MMP-3、MMP-9 和 MMP-8 表现出抑制活性，其半抑制浓度（IC50s）分别为 0.65 nM、0.39 μM、0.98 μM 和 1.7 μM。在 AH[1] 存在的条件下，PF-00356231 hydrochloride 能降低 MMP-12（0.014 μM）和 MMP-13（0.27 μM）的 IC50 值。 |
| Target activity | MMP9:0.98 μM, MMP12:1.4 μM, MMP8:1.7 μM, MMP13:0.65 nM, MMP3:0.39 μM |
| molecular weight | 464.96 |
| Molecular formula | C25H21ClN2O3S |
| CAS | 820223-77-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 18.9 mg/mL (40.6 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. |