| Description | CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM). |
| In vitro | CID-1067700 binds the nucleotide binding pocket of Rab7 with a Ki value of 13 nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively[1]. |
| Target activity | Rab7:13 nM |
| Synonyms | 2-[[(苯甲酰基氨基)硫代甲酰]氨基]-4,7-二氢-5,5-二甲基-5H-噻吩并[2,3-C]吡喃-3-羧酸 |
| molecular weight | 390.48 |
| Molecular formula | C18H18N2O4S2 |
| CAS | 314042-01-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 68 mg/mL(174 mM), Sonication is recommended. |
| References | 1. Agola J O , Hong L , Surviladze Z , et al. A Competitive Nucleotide Binding Inhibitor:\r, In Vitro\r, Characterization of Rab7 GTPase Inhibition[J]. ACS Chemical Biology, 2012, 7(6):1095-1108. 2. Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. 2019(6):724-736. |