| Description | Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE application. |
| Synonyms | Epoxycholesterol, 5α,6α-epoxy Cholestanol, NSC 18176 |
| molecular weight | 402.65 |
| Molecular formula | C27H46O2 |
| CAS | 1250-95-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: ≤ 20 mg/mL DMF: 2 mg/mL DMSO: 0.1 mg/mL |
| References | 1. Villalpando, D.M., Rojas, M.M., García, H.S., et al. Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. PLoS One 12(10), e0185805 (2017). 2. Segala, G., de Medina, P., Iuliano, L., et al. 5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells. Biochem. Pharmacol. 86(1), 175-189 (2013). 3. Testa, G., Staurenghi, E., Zerbinati, C., et al. Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation. Redox Biol. 10, 24-33 (2016). |