| Description | BU 226 hydrochloride demonstrates affinity for imidazoline (I) receptors, in particular the I2 binding site with a Ki of 1.4 nM. BU 226 hydrochloride showed low (microM) affinity for alpha 2-adrenoceptors. |
| Target activity | Imidazoline receptor:1.4 nM (Ki) |
| molecular weight | 233.7 |
| Molecular formula | C12H12ClN3 |
| CAS | 1186195-56-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.28 mg/mL (9.74 mM) |
| References | 1. Hudson AL, et al. Novel selective compounds for the investigation of imidazoline receptors. Ann N Y Acad Sci. 1999 Jun 21;881:81-91. 2. Anderson NJ, et al. Characterisation of imidazoline I2 binding sites in pig brain. Eur J Pharmacol. 2005 Sep 5;519(1-2):68-74. |