| Description | BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities. |
| In vivo | BU 224 hydrochloride (5 mg/kg; i.p.) 在5XFAD小鼠中减轻了空间及视皮质依赖的识别记忆缺陷。恐惧条件测试显示，BU 224 hydrochloride 同时改善了转基因小鼠中的关联学习以及海马和杏仁体依赖的记忆，但在WT小鼠中则没有这种效果。在大脑中，BU 224 hydrochloride 降低了5XFAD小鼠中的微胶质标志物Iba1和促炎细胞因子IL-1β及TNF-α的水平，并增加了星形胶质细胞标志物GFAP的表达[1]。 |
| molecular weight | 233.7 |
| Molecular formula | C12H12ClN3 |
| CAS | 205437-64-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3 mg/mL (12.84 mM), Sonication is recommended. |
| References | 1. Mirzaei N, et al. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178(3):654-671. 2. Min JW, et al. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. Eur J Pharmacol. 2013 Oct 15;718(1-3):81-6. |