| Description | 2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease. |
| In vivo | 给予2-BFI hydrochloride治疗后，可改善dMCAO后的神经功能缺损并减少梗塞体积。2-BFI hydrochloride降低了mTOR和p70S6的磷酸化，增加了IL-10和TGF-β水平，减少了缺血大鼠的IFN-γ水平。通过抑制mTOR信号的激活并调节大鼠中风后的神经炎症，2-BFI hydrochloride减轻了缺血性损伤[2]。 |
| molecular weight | 222.67 |
| Molecular formula | C11H11ClN2O |
| CAS | 89196-95-2 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20 mg/mL (89.8 mM) |
| References | 1. Soto CJ, John OP. The next Big Five Inventory (BFI-2): Developing and assessing a hierarchical model with 15 facets to enhance bandwidth, fidelity, and predictive power. J Pers Soc Psychol. 2017 Jul;113(1):117-143. 2. Cheng Y, et al. 2-BFI attenuates ischemic injury by modulating mTOR signaling and neuroinflammation in rats. Neurosci Lett. 2021 Apr 17;750:135766. |