| Description | BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner. |
| In vivo | 当以 BI-6901 以100 mg/kg ip bid 给药时,BI-6901 在小鼠接触超敏反应的 DNFB 模型中有效,能够剂量依赖性抑制 DNFB 刺激致敏 Balb-C 小鼠的炎症反应[1]。 |
| molecular weight | 453.56 |
| Molecular formula | C23H27N5O3S |
| CAS | 2040401-92-9 |
| Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 120 mg/mL (264.57 mM), Sonication is recommended. |
| References | 1. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. |