| Description | Mtb ATP synthase-IN-1 is an orally available inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthesis for the study of Mycobacterium tuberculosis infections. |
| In vivo | 在雄性 CD-1小鼠中，Mtb ATP synthase-IN-1 ( PO 50 mg/kg , IV 5 mg/kg ;单次给药;药动学分析)具有良好的代谢稳定性和可接受的口服生物利用度[1]。 |
| Target activity | Mtb:0.452-0.499 μg/mL(MIC) |
| molecular weight | 323.30 |
| Molecular formula | C17H13N3O4 |
| CAS | 2642394-38-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (309.31 mM), Sonication is recommended. |
| References | 1. Li P, et al. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur J Med Chem. 2020;206:112538. |