| Description | Basiliximab (CHI 621) is a chimeric mouse/human IgG1 monoclonal recombinant antibody against the interleukin-2 receptor. Basiliximab has good immunosuppressive activity and can be used in the study of kidney transplantation. |
| In vitro | Specifically inhibiting T lymphocyte proliferation, Basiliximab binds to IL-2Rα[1]. It binds only to activated lymphocytes and macrophages/monocytes[3]. Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα[2]. |
| Synonyms | CHI 621 |
| molecular weight | N/A |
| CAS | 179045-86-4 |
| Storage | store at low temperature | store at -20°C |
| References | 1. McKeage K, et al. Basiliximab: a review of its use as induction therapy in renal transplantation. BioDrugs. 2010 Feb 1;24(1):55-76. 2. Chapman TM, et al. Basiliximab: a review of its use as induction therapy in renal transplantation. Drugs. 2003;63(24):2803-35. |