| Description | BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B. longum BSH and B. theta BSH). |
| In vitro | BSH-IN-1对生长中的革兰阴性菌（Bacteroides fragilis ATCC 25285、B. theta VPI-5482以及Bacteroides vulgatus ATCC 8482）和革兰阳性菌（C. perfringens ATCC 13124、Lactobacillus plantarum WCFS1及Bifidobacterium adolescentis L2–32）均表现出抑制BSH活性的作用。在细菌培养中，BSH-IN-1是一种 BSH抑制剂，对B. adolescentis的IC50为237 nM，对B. theta的IC50为1070 nM。 |
| In vivo | 在C57BL/6小鼠中，BSH-IN-1（10 mg/kg；单剂量；灌胃）能够抑制BSH活性，并可能限于肠道。 |
| molecular weight | 408.59 |
| Molecular formula | C25H41FO3 |
| CAS | 2553217-91-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL (97.9 mM), Sonication is recommended. |
| References | 1. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases.Nat Chem Biol. 2020 Mar;16(3):318-326. |