| Description | BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2). |
| Target activity | BACE2 (human):47 nM , BACE1 (human):32 nM |
| molecular weight | 389.33 |
| Molecular formula | C18H14F3N5O2 |
| CAS | 1310347-50-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. |