| Description | AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM). |
| Target activity | BACE1:, BACE2:18.6 nM |
| molecular weight | 473.5 |
| Molecular formula | C22H21F2N5O3S |
| CAS | 1874232-80-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Pettus LH, Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. J Med Chem. 2019 Oct 18. |