| Description | BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2. |
| In vitro | BACE1-IN-4 (Compound 22) is a BACE1 inhibitor, more selective at BACE1 over BACE2 (IC50, 2090 nM; Ki, 1740 nM). |
| Target activity | BACE1:(ki)1.9 nM , BACE1:3.8 nM , BACE2:1740 nM , BACE2:2090 nM |
| molecular weight | 511.57 |
| Molecular formula | C21H23F2N5O4S2 |
| CAS | 2361157-92-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62(10):5080-5095. |