| Description | 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. |
| In vitro | 通过现代光谱分析和X射线晶体学鉴定，一种新的质粒消除化合物被识别为8-Epidiosbulbin E acetate(EEA)(norditerpene)。EEA展现了针对多重耐药(MDR)细菌的广谱质粒消除活性，包括对万古霉素耐药的肠球菌。EEA能从临床分离的屎肠球菌、大肠杆菌、索尼氏志贺菌和铜绿假单胞菌中消除抗生素耐药质粒(R-plasmids)，消除效率在12-48%之间。而对于枯草杆菌(pUB110)、大肠杆菌(RP4)、铜绿假单胞菌(RIP64)和伤寒沙门氏菌(R136)的参考质粒，则具有16%至64%的消除效率。EEA介导的R-质粒消除降低了对MDR细菌的最小抑菌浓度，从而使抗生素治疗更为有效。 |
| Synonyms | 8-表黄药子素E乙酸酯 |
| molecular weight | 388.41 |
| Molecular formula | C21H24O7 |
| CAS | 91095-48-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (141.6 mM) |
| References | 1. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria.Int J Antimicrob Agents. 2008 Nov;32(5):405-10. |