| Description | ARS-1620 is a covalent inhibitor of K-RASG12C. |
| In vivo | ARS-1620 (200 mg/kg) induces tumor regression in a MIA-PaCa2, but not an H441, mouse xenograft model.?It also decreases tumor volume in patient-derived xenograft (PDX) mouse models expressing K-RASG12C, but not K-RASG12D or wild-type K-RAS. |
| molecular weight | 430.84 |
| Molecular formula | C21H17ClF2N4O2 |
| CAS | 1698055-85-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 53 mg/mL (123.02 mM) |
| References | 1. Janes M R , Zhang J , Li L S , et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor[J]. Cell, 2018, 172(3):578-589.e17. |