| Description | Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties. |
| In vitro | Ex vivo guinea pig airway rings, human ASM strips and small peripheral airways in rat lungs slices relaxed in response to niflumic acid following depolarization-induced contraction induced by K(+) channel blockade with tetraethylammonium chloride (TEA).?In isolated human airway smooth muscle cells TEA induce depolarization as measured by a fluorescent indicator or whole cell patch clamp and this depolarization was reversed by niflumic acid[1]. |
| molecular weight | 165.7 |
| Molecular formula | C8H20ClN |
| CAS | 56-34-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 32.5 mg/mL (196.13 mM) H2O: 100 mg/mL (603.50 mM), Sonication is recommended. |
| References | 1. Yim P D , George G , Perez-Zoghbi J F , et al. Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle[J]. Journal of Smooth Muscle Research, 2013, 49:112-124. 2. Walcher D N , Scott J R , Ekstam F C . EFFECT OF TETRAETHYLAMMONIUM CHLORIDE (ETAMON CHLORIDE) ON MUSCLE SPASM IN POLIOMYELITIS[J]. Pediatrics, 1951, 7(4):524-528. |