| Description | α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. |
| Synonyms | MSH, amide, CZEN-002, 美拉诺坦, α-Melanocyte-Stimulating Hormone (MSH), amide |
| molecular weight | 1664.89 |
| Molecular formula | C77H109N21O19S |
| CAS | 581-05-5 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. Jo H, et al. Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3374-3377. 2. Jo H , Choi M , Sim J , et al. Synthesis and Biological Evaluation of Caffeic Acid Derivatives as Potent Inhibitors of α-MSH-stimulated Melanogenesis[J]. Bioorganic & Medicinal Chemistry Letters, 2017:S0960894X17306133. 3. Lu X Y , Barsh G S , Akil H , et al. Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2003, 23(21):7863. |
| Citations | 1. Zhang L, Wan M, Tohti R, et al.Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.International Journal of Molecular Sciences.2022, 23(22): 14182. |