| Description | Canocapavir (ZM-H1505R) is a novel orally available HBV coat protein modulator with antiviral activity that induces conformational changes in the linker region of the HBV core protein, and can be used for the treatment of hepatitis B virus. |
| Synonyms | ZM-H1505R |
| molecular weight | 562.39 |
| Molecular formula | C27H21BrFN5O3 |
| CAS | 2137847-19-7 |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (177.81 mM), Sonication is recommended. |
| References | 1. Jia H,et al. Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial. BMC Med. 2023 Mar 16;21(1):98. 2. Zheng Y,et al. Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein. Viruses. 2023 May 18;15(5):1195. |