| Description | ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity. |
| In vitro | 相较于内源性的ML cGAMP及TLR3激动剂poly I:C，ADU-S100 ammonium salt 在摩尔等效基础上诱导IFN-β、促炎细胞因子TNF-α、IL-6和MCP-1的表达最为明显。此外，ADU-S100 ammonium salt 还能促进小鼠骨髓巨噬细胞中STING的聚集，并诱导TBK1和IRF3的磷酸化。与ML cGAMP[1]比较，ADU-S100 ammonium salt 显著提高了IFN-α的水平。 |
| In vivo | 在BALB/c小鼠携带的双侧CT26或4T1肿瘤中，将ADU-S100 ammonium salt 通过IT（肿瘤内）注射至其中一个肿瘤，能促进对侧未经治疗的肿瘤退缩。ADU-S100 ammonium salt 的IT注射能够清除多种肿瘤类型，并激活有效的全身CD8+ T细胞免疫应答，显著抑制远处未经治疗的病灶[1]的生长。 |
| Synonyms | ML RR-S2 CDA ammonium salt, MIW815 ammonium salt |
| molecular weight | 724.6 |
| Molecular formula | C20H30N12O10P2S2 |
| CAS | 1638750-96-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 5 mg/mL (6.90 mM), Sonication is recommended. DMSO: 12 mg/mL (16.58 mM), Sonication and heating are recommended. |
| References | 1. Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30. |