| Description | STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM). |
| In vitro | STING agonist-4 （0.3-30 μM；2小时）促进IRF3和STING的磷酸化作用，并且其过程可以被TBK1抑制剂BX795所抑制，同时诱导剂量依赖性的IFN-β分泌，其中EC50值为3.1 μM。在0.001 nM至1 μM的浓度范围内，STING agonist-4 抑制了全长STING与固相载体的结合（Kd: 1.6 nM）。STING agonist-4 在0至100 μM的剂量中，其潜力是内源性STING配体cGAMP的18倍（EC50为53.9 μM）。STING agonist-4 在3 μM浓度下作用4小时，通过STING介导的TBK1活化机制促进干扰素γ诱导的蛋白10（IP-10）、IL-6和TNF-α的产生。 |
| Target activity | STING agonist-4:20 nM |
| molecular weight | 678.74 |
| Molecular formula | C34H38N12O4 |
| CAS | 2138300-40-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (14.73 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) |
| References | 1. Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Dec;564(7736):439-443. |