| Description | AB-423 is an inhibitor of HBV capsid assembly, and potently inhibits HBV replication (EC50/EC90: 0.08-0.27 μM/0.33-1.32 μM in cells). |
| In vitro | AB-423 shows an inhibitory effect on relaxed circular DNA production in AML12-HBV10 and HepDE19 cells (EC50s: ～0.260 μM). AB-423 also suppresses cccDNA formation-dependent HBeAg production in the HepBHAe82 assay (EC50: 0.267 μM) and inhibits HBV DNA levels in culture supernatants of HepG 2.2.15 cells (EC50: 0.134 μM). |
| molecular weight | 386.39 |
| Molecular formula | C17H17F3N2O3S |
| CAS | 1572510-80-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (155.28 mM), Sonication and heating are recommended. |
| References | 1. Mani N, et al. Preclinical profile of AB-423, an inhibitor of Hepatitis B virus pgRNA encapsidation. Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00082-18. |