| Description | Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM). |
| In vitro | 卡拉胶注射后引起的水肿具有双相性质。初期阶段从卡拉胶给药后1小时开始，其原因是组胺和血清素的释放。第二阶段发生在卡拉胶给药后2至5小时，由缓激肽、蛋白酶、前列腺素及溶酶体的释放引起。已有报告称，水肿的第二阶段对大多数临床有效的抗炎化合物（如消炎痛）敏感。然而，使用番石榴素和Punicalin治疗可以对抗卡拉胶引起的两个炎症阶段。 |
| In vivo | Punicalagin 和 punicalin 是 T. catappa L. 的活性成分，这是一种在南亚使用的具有保肝作用的药材，它们被发现有极好的抗氧化活性和对 CC14 或对乙酰氨基酚引起的肝损伤有保护作用。即使它们在体外较小浓度时具有很好的抗氧化效果，但用较大剂量的 Punicalagin 和 punicalin 治疗会导致大鼠肝细胞损伤。在研究它们的抗炎作用时，也观察到了相似的结果。 |
| Animal experiments | Edema in the left hind paw of rats was induced by injecting 0.05 ml of 1% (w/v) carrageenan into the limb.?Animals were divided into six groups with eight animals in each group.?The drug test groups were treated with 5 or 10 mg/kg body weight of each component 1 hr before carrageenan injection.?The animals in the control group received saline.?Another group of rats was administered 5 mg/kg indomethacin as a standard anti-inflammatory drug. |
| Target activity | HIV-1:0.11 microg/ml |
| molecular weight | 782.53 |
| Molecular formula | C34H22O22 |
| CAS | 65995-64-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (31.95 mM) |
| References | 1. Lin CC, et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.Am J Chin Med. 1999;27(3-4):371-6. |
| Citations | 1. Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762. |