| Description | Pamidronate Disodium (CGP 23339A), a nitrogen-containing bisphosphonate, can help to strengthen bones. |
| In vitro | 在卵巢切除大鼠中,Pamidronate显着增加骨密度和灰质重量.在用生长激素（GH）处理的大鼠中,Pamidronate降低的IGF-I水平. |
| In vivo | 在人成骨细胞中,Pamidronate（1 μM）以剂量依赖的方式增加OPG mRNA水平和蛋白分泌。马在破骨样细胞中（IC50=0.58 μM）,Pamidronate抑制吸收磷酸钙薄膜。 |
| Synonyms | 帕米膦酸钠, CGP 23339A, CGP 23339AE, Pamidronate disodium salt |
| molecular weight | 279.03 |
| Molecular formula | C3H9NNa2O7P2 |
| CAS | 57248-88-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Insoluble H2O: 10 mM |
| References | 1. Viereck V, et al. Biochem Biophys Res Commun,2002, 291(3), 680-686. 2. Fitton A, et al. Drugs,1991, 41(2), 289-318. 3. Gray AW, et al. Res Vet Sci,2002, 72(2), 105-113. 4. Kapitola J, et al. Physiol Res,1998, 47(4), 237-240. 5. Kapitola J, et al. Physiol Res,2000, 49, S101-106. |