| Description | Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65. |
| In vitro | 为了探索具有抗糖尿病和提升胰岛素敏感性的天然产品，通过使用Oil Red O染色技术评估在3T3-L1前脂肪细胞中的脂肪积累来研究其对脂肪细胞分化的影响。方法与结果：通过多种色谱方法对巴戟天（Morinda officinalis，马钱科）的正己烷和CHCl₃部分进行分离和提取，从而分离出三种蒽醌类化合物，1,2-二甲氧基蒽醌（1）、茜素-2-甲基醚（2）和Rubiadin-1-甲基醚（3）。在这些成分中，茜素-2-甲基醚（2）显示出最强的增强活性，其次是Rubiadin 1-甲基醚（3）和1,2-二甲氧基蒽醌（1）。在100 μM的浓度下，茜素-2-甲基醚（2）可将脂肪细胞分化增强至131%（与胰岛素处理的细胞相比）。结论：因此，这些化合物可能对糖尿病治疗有益。 |
| Synonyms | Rubiadin 1-methyl ether, 3-羟基-1-甲氧基-2-甲基蒽醌 |
| molecular weight | 268.26 |
| Molecular formula | C16H12O4 |
| CAS | 7460-43-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.68 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells. Nat Prod Res. 2012;26(18):1750-4. 2. Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum. Planta Med. 1992 Dec;58(6):533-4. 3. Natural anthraquinones probed as Type I and Type II photosensitizers: singlet oxygen and superoxide anion production. J Photochem Photobiol B. 2005 Jan 14;78(1):77-83. |