| Description | 7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery. |
| In vivo | 在雄性Sprague-Dawley大鼠中，7-Chlorokynurenic acid（10 nM）延缓了癫痫反应的电脑图及运动（每日17.7次刺激）组分的发展[3]。 |
| Target activity | Glycine B coagonist site of NMDA receptor:0.56 μM(ki), Reuptake of glutamate:（ki）0.59 μM |
| Synonyms | 7-chloro-4-hydroxy-2-carboxyquinoline, 7-氯犬尿酸, 7-CKA |
| molecular weight | 223.61 |
| Molecular formula | C10H6ClNO3 |
| CAS | 18000-24-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 15 mg/mL (67.1 mM), Sonication is recommended. |
| References | 1. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50. 2. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196. 3. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32. |