| Description | IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
| In vitro | IEM 1754是一种腺苷酸型衍生物。它会导致依赖使用和电压的方式阻断重组AMPA受体开放通道。这种对立作用取决于受体亚基组成，由重组的、同源的GluR1和GluR3受体控制的通道对阻断的敏感性高于含有经过编辑的GluR2亚基的受体控制的通道。[1] IEM-1754对含GluR2的AMPAR的阻断在超极化条件下增强，这与经典的单指数模型相符。相反，缺乏GluR2的AMPAR的阻断在超极化条件下降低。[2] |
| Target activity | GluR1:6 μM |
| Synonyms | IEM 1754 dihydrobromide |
| molecular weight | 412.25 |
| Molecular formula | C16H30N2·2HBr |
| CAS | 162831-31-4 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 75 mg/mL (181.9 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (121.29 mM), Sonication is recommended. |
| References | 1. Magazanik LG, et al. J Physiol, 1997, 505( Pt 3), 655-663. 2. Tikhonov DB, et al. Br J Pharmacol, 2000, 129(2), 265-274. |