| Description | Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) has research value in schizophrenia. |
| In vitro | Pomaglumetad methionil (LY2140023) 作为一种具有高亲和力的肽转运体1 (PEPT1) 底物，其Km值约为30 µM。LY2140023 对 [14C]Gly-Sar 显示出活性，IC50 值为0.018 mM。 |
| In vivo | Pomaglumetad methionil (LY2140023; 口服；3-300 mg/kg；每日一次，连续7天) 通过剂量依赖性方式增加多巴胺代谢产物二羟基苯乙酸（DOPAC）和高香草酸（HVA）的水平[1]。 |
| Synonyms | LY2140023 hydrochloride |
| molecular weight | 402.87 |
| Molecular formula | C12H19ClN2O7S2 |
| CAS | 635318-26-2 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (55.8 mM), Sonication is recommended. |
| References | 1. Lowe S, et al. Effects of a novel mGlu₂/₃ receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70. 2. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144. |
Pomaglumetad methionil hydrochloride
CAS No.: 635318-26-2
Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity.
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