| Description | 13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug |
| In vitro | 我们对11种原始骨碱和2种苯并菲安全碱类化合物进行筛选，评估它们对3T3-L1脂肪细胞的抗脂肪生成效果，发现13-Methylberberine chloride显示出最强的活性。13-Methylberberine chloride降低了主要脂肪细胞分化转录因子，过氧化物酶体增殖物激活受体γ (PPARγ) 和CCAAT增强子结合蛋白α (C/EBPα±) 以及它们的靶基因的表达。PPARγ、C/EBPα±和固醇调节元素结合蛋白1 (SREBP-1) 的蛋白水平降低，且这种降脂效果被AMP激活蛋白激酶 (AMPK) 抑制剂削弱，表明该化合物的作用需要AMPK信号通路。Akt磷酸化的减少提示了新生脂质合成的减少。C-13甲基替换的小檗碱增加了在处理细胞中的积累，表明13-Methylberberine chloride与小檗碱相比有更好的吸收和更高的积累。 |
| Synonyms | 13-甲基小檗碱, 13-Methylberberine |
| molecular weight | 385.84 |
| Molecular formula | C21H20ClNO4 |
| CAS | 54260-72-9 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 10 mg/mL (25.92 mM) |
| References | 1. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells.Sci Rep. 2016 Dec 5;6:38129. |
| Citations | 1. Liang X, Cao Y, Duan Z, et al.Discovery of New Small Molecule Inhibitors of the BPTF Bromodomain.Bioorganic Chemistry.2023: 106453. |