1-Deoxymannojirimycin hydrochloride Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	1-Deoxymannojirimycin hydrochloride is a selective α1,2-mannosidase inhibitor(IC50: 20 μM). 1-Deoxymannojirimycin hydrochloride also inhibits HIV‐1 strains and has poor antiviral activity.
In vitro	将这类突变病毒株暴露于1-Deoxymannojirimycin下，在CEM细胞培养中可以增强对突变病毒引起的细胞病变的抑制[1]。当与表现出较弱或几乎没有抑制突变病毒复制能力的CBAs联合使用时，观察到1-Deoxymannojirimycin具有协同的抗病毒活性[1]。
Target activity	α1/2 mannosidase I:20 μM
molecular weight	199.63
Molecular formula	C6H14ClNO4
CAS	73465-43-7
Storage	store at low temperature\|Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 20 mg/mL (100.19 mM) H2O: 20 mg/mL (100.19 mM)
References	1. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. 2. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.

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