| Description | DC-Chol hydrochloride(DC-Cholesterol hydrochloride) inhibited the formation of Aβ40 fibrils under appropriate experimental conditions and significantly inhibited amyloid formation from oxidized hCT in a dose-dependent manner.DC-Chol hydrochloride induces an improved and balanced immunity, which could contribute to hepatitis B vaccine research. |
| Synonyms | Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride, DC-Chol (hydrochloride), DC-Cholesterol hydrochloride, Cholesteryl 3β-N-(dimethylaminoethyl)carbamate |
| molecular weight | 537.26 |
| Molecular formula | C32H57ClN2O2 |
| CAS | 166023-21-8 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL, Sonication is recommended. Methanol: 10 mg/mL Ethanol: 20 mg/mL (37.23 mM), Sonication is recommended. |
| References | 1. Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120(1):59-68. 2. Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111(5):e23343. 3. Myschik J, et al. Immunostimulatory lipid implants containing Quil-A and DC-cholesterol. Int J Pharm. 2008 Nov 3;363(1-2):91-8. 4. Chang SF, et al. The Impact of Lipid Types and Liposomal Formulations on Osteoblast Adiposity and Mineralization. Molecules. 2018 Jan 2;23(1):95. 5. López-Dávila V, et al. Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model. Nanomedicine (Lond). 2016 Feb;11(4):331-44. |