| Description | Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis. |
| In vitro | Sinensetin在不完全分化培养基中促进3T3-L1前脂肪细胞的成脂作用，并通过提高cAMP水平增强成脂和脂解作用。Sinensetin通过调节抑制剂κB-α（IκB-α）蛋白水平展现出抗炎活性。 |
| In vivo | Sinensetin 在具有最強的抗血管生成活性和最低的毒性方面表現突出，通过在HUVEC培养中诱导细胞周期在G0/G1阶段停滞以及在斑马鱼中下调血管生成基因flt1、kdrl和hras的mRNA表达来抑制血管生成。 |
| Synonyms | Pedalitin permethyl ether, 甜橙素 |
| molecular weight | 372.37 |
| Molecular formula | C20H20O7 |
| CAS | 2306-27-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.72 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8. 2. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9. 3. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56. |