| Description | Protopanaxatriol (20(R)-APPT), a major ginseng constituent, is a novel PPARγ antagonist. |
| Synonyms | 20(R)-APPT, 20(R)-Protopanaxatriol, 原人参三醇, (20R)-Protopanaxatriol |
| molecular weight | 476.73 |
| Molecular formula | C30H52O4 |
| CAS | 1453-93-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (20.98 mM), Sonication is recommended. |
| References | 1. Zhang Y, et al. Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice. Sci Rep. 2014 Dec 9;4:7375. 2. Ahn HY, et al. Panax ginseng extract rich in ginsenoside protopanaxatriol offers combinatorial effects in nitric oxide production via multiple signaling pathways. Springerplus. 2013 Mar 9;2(1):96. 3. Kong LT, et al. Different pharmacokinetics of the two structurally similar dammarane sapogenins, protopanaxatriol and protopanaxadiol, in rats. Fitoterapia. 2013 Apr;86:48-53. 4. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786. |