| Description | Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. |
| Synonyms | 黑海常春藤苷A1, 革叶常春藤皂苷 A1, Raddeanoside R13 |
| molecular weight | 897.1 |
| Molecular formula | C47H76O16 |
| CAS | 106577-39-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 83.3 mg/mL (92.89 mM ), Sonication is recommended. |
| References | 1. Wang L , Wang Z , Su S , et al. Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins[J]. Carbohydrate Research, 2017, 442:9-16. 2. Barthomeuf C , Boivin D , Richard Béliveau. Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade[J]. Cancer Chemotherapy & Pharmacology, 2004, 54(5):432-440. 3. Delmas F, Giorgio C D , Elias R , et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro.[J]. Planta Medica, 2000, 66(04):343-347. |